Section 11:   Toxicological information

The calculation of the classification according to 67/548/EEC is mainly based on toxicological data. The data can be determined by testing a substance or product, but usually are found by a comprehensive search in databases and related literature.

In case of inaccessible data, comparision with similar substance or product could be used, but should be clearly mentioned in the MSDS.

Toxicological information includes:

Acute toxicity (divided into oral, inhalational and dermal application)

Irritant effects to skin and eyes Sensitization

Chronic toxicity Mutagenicity

Teratogenicity Carcinogenicity

Mutagenicity, teratogenicity and carcinogenicity have been classified for several compounds by several European institutions. They are also listed in the DFG publication "MAK- und BAT-Werte".

All products and substances or ingredients are listed in the European List of New Chemical Substances (ELINCS) or the European Inventory of Existing Chemical Substances (EINECS). If they are not, they may not be traded in Europe unless they are registered first.

EXAMPLE MSDS for ACRYLONITRILE

11.TOXICOLOGICAL INFORMATION

acute toxicity:
LD50 oral, rat: 78 mg/kg
LD50 dermal, rabbit: 250 mg/kg
LD50 inhalation, rat: 500 ppm, 4h exposure
Toxic by inhalation, in contact with skin and if swallowed.
Symtoms of poisoning: headache, nausea, vomiting. 
If a substantial quantity is taken in or absorbed, 
the symtons are unconsciousness, spasm, cessation of brathing. 
Skin contact can result in large blisters which may only heal slowly. 
The eyes and mucous membranes are particularly at risk.